GLP-2 TRZ

GLP-2 TRZ is a synthetic 39-residue peptide catalogued as a dual incretin receptor agonist, characterised in published work by activity at both the GIP and GLP-1 receptor families rather than at one alone.

Two structural features are cited in its characterisation. A C20 fatty diacid moiety is attached through a linker to a lysine residue, which promotes albumin binding, and the backbone incorporates non-natural residues including aminoisobutyric acid at positions where the native sequences are susceptible to dipeptidyl peptidase-4 cleavage. Both are why the analogue is described as long-acting relative to the native incretins.

The dual receptor activity is what separates this class from single-receptor incretin analogues, and is the basis on which it appears separately in preclinical literature.

Supplied in 10mg, 20mg, 40mg and 60mg presentations as lyophilised powder in a 3ml vial.

Supplied as a lyophilised (freeze-dried) powder in a sealed vial under vacuum. Lyophilisation removes water by sublimation, which is what allows a peptide to remain stable at ambient temperature during transit where a solution would degrade.

Reconstitution in a laboratory setting is typically performed with bacteriostatic water, introduced slowly against the vial wall rather than directly onto the powder cake. Peptide bonds are susceptible to shear, so the vial is swirled to dissolve rather than shaken.

Lyophilised and sealed, the vial is stable at 2 to 8 degrees Celsius and tolerates ambient temperature in transit. For storage beyond several months, minus 20 degrees Celsius is standard.

Once in solution the stability window shortens considerably and refrigeration is required. Repeated freeze-thaw cycles are the most common cause of degradation in a reconstituted peptide, so solutions are generally aliquoted rather than frozen and thawed as a single volume.

Every batch is independently tested through seven rounds of analysis. Identity is confirmed by mass spectrometry and purity quantified by reverse-phase HPLC, with the resulting Certificate of Analysis published against the specific batch rather than the product line.

Testing is performed by third-party laboratories operating to ISO 17025. The COA for the batch currently shipping is linked from this page and archived at /lab-tests.